Enclomiphene is a selective estrogen receptor modulator (SERM) and the trans-isomer of clomiphene citrate. It is researched for testosterone restoration and male fertility support by blocking estrogen receptors in the hypothalamus, thereby stimulating endogenous hormone production without direct androgen supplementation.
Category: Hormonal & Reproductive. Evidence rating: B (meaningful human data).
Clinical status: Phase III completed but FDA approval denied (2015). Available through compounding pharmacies and research suppliers.
Blocks estrogen receptors in the hypothalamus, preventing negative feedback inhibition. This stimulates GnRH release, which in turn increases LH and FSH secretion from the pituitary, boosting endogenous testosterone production while preserving fertility and spermatogenesis.
Safety considerations: Generally well-tolerated in clinical trials; Headache, nausea, and hot flashes reported; Visual disturbances possible (SERM class effect).
Reviewed by the PeptideAtlas Editorial Team. Last reviewed: 2026-07-05.
Related peptides: Kisspeptin-10.
Compare: Enclomiphene vs Kisspeptin-10.
No, it is a small-molecule SERM (selective estrogen receptor modulator). It is included in peptide databases because it is commonly used alongside peptide protocols for hormone optimization.
Clomid (clomiphene citrate) is a mixture of two isomers: enclomiphene (trans) and zuclomiphene (cis). Enclomiphene is the active isomer responsible for testosterone-boosting effects, while zuclomiphene has longer half-life and estrogenic activity that causes more side effects.
Enclomiphene is a selective estrogen receptor modulator (SERM) researched for testosterone restoration and male fertility support. It is the trans-isomer of clomiphene with a more targeted receptor profile.
ENCLOMIPHENE has been studied for: Testosterone restoration, Fertility support, Estrogen modulation, Endogenous hormone optimization. Not a peptide; SERM. Commonly sold alongside peptides by research vendors.
Blocks estrogen receptors in the hypothalamus, stimulating LH and FSH release to boost endogenous testosterone production without direct androgen supplementation.