Adamax is a synthetic derivative of Semax featuring an adamantane moiety that enhances blood-brain barrier (BBB) penetration and extends its half-life. Like Semax, it is derived from the ACTH(4-10) fragment but with additional N-acetyl and C-terminal adamantyl modifications. It is proposed to increase BDNF expression more potently than standard Semax and may have stronger nootropic and neuroprotective effects. No human clinical trials exist; all evidence is preclinical or anecdotal from self-experimenters.
1 independent Janoshik purity test cover Adamax across 1 vendor.
Category: Cognitive / Nootropic. Evidence rating: D (animal/preclinical only).
Clinical status: No clinical trials. Research chemical based on Semax structure.
Adamax retains the ACTH(4-7) core pharmacophore (Met-Glu-His-Phe) responsible for neurotrophin modulation while the adamantane group increases lipophilicity and BBB penetration. It is theorized to activate TrkB receptor signaling, increase BDNF and NGF expression, modulate dopaminergic and…
Safety considerations: No formal safety data available; Anecdotal reports suggest similar side effect profile to Semax: mild headache, nasal dryness (intranasal), irritability at high doses; Theoretical concern about excessive BDNF elevation with chronic use.
Reviewed by the PeptideAtlas Editorial Team.
| Half-life | ~4-6 hours (estimated, extended by adamantane) |
|---|---|
| Bioavailability | High SC; enhanced BBB penetration |
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | Unregulated research chemical. Not FDA-approved or reviewed. |
| Vendor | Best tested purity |
|---|---|
| Qingdao Sigma Chemical QSC | 99.6% |
Adamax adds an adamantane group to the Semax molecule, theoretically increasing BBB penetration and extending half-life. However, this difference has not been validated in published clinical or preclinical studies.
There is no clinical safety data for Adamax. Users extrapolate safety from Semax data, but the adamantane modification could introduce unique risks. Use at your own risk.
Adamax is an enhanced variant of Semax, developed for cognitive enhancement research. It is a synthetic peptide with reported nootropic properties.
ADAMAX has been studied for: Cognitive enhancement, Nootropic effects, Mental clarity. Enhanced semax variant; nootropic focus.
Modified ACTH fragment that may influence neurotransmitter activity and brain-derived neurotrophic factor (BDNF) levels.